Please see Bibliography of References for a list of abstracts, manuscripts and posters.
Cohn SM, Varela E, Giannotti G, Dolich M, Brown M, Feinstein A, Ara BA, McKenney M, Spalding P. J Trauma. 2001;50(4):629-635.
Objective: The purpose of this study was to use a prototype side-illuminating near-infrared spectroscopy (NIRS) nasogastric probe to continuously measure changes in gastric tissue oxygen saturation (StO2) in a pig hemorrhage model.
Methods: Swine (n = 12; 6 per group) underwent laparotomy and placement of a gastric NIRS probe, jejunal tonometer, superior mesenteric artery (SMA) flow probe, and a portal vein catheter. Animals underwent hemorrhage (28 mL/kg) t = 0 to 20 minutes (where t = time). Pigs in group I were resuscitated (t = 20–40 minutes) with lactated Ringer’s solution (84 mL/kg), whereas group II had no resuscitation.
Results: A significant decrease in mean arterial pressure and SMA flow was observed after hemorrhage. SMA flow significantly correlated in group I with both NIRS StO2 (r = 0.58, p = 0.0001) and regional CO2 (r = 20.54, p = 0.0001). In group II, superior mesenteric flow correlated with NIRS StO2 (r = 0.30, p = 0.03), but not regional CO2 (r = -0.23, p = 0.09).
Conclusion: Direct measurement of tissue oxygen saturation with a prototype side-illuminating near-infrared spectroscopy gastric probe appeared to rapidly reflect changes in splanchnic perfusion.