Please see Bibliography of References for a list of abstracts, manuscripts and posters.
Borrat X, Sanchez-Etayo G, Mercadal J, Tercero F, De la Riba N, Israel T, Adalia R, Zabala E. Int Care Med. 2006;32(Supp 1):S172. Abstract 0657.
Introduction: There is evidence that the development of MOF, and ultimately death is closely related to impaired microcirculation. As a preliminary study, we analyzed the StO2 in three different types of patients to assess the differences in the microcirculation pattern between septic, healthy and hemorrhagic shock patients.
Methods: We studied twelve patients (four polytraumatized (PLT), four shock septic (SEPTIC) patients and four healthy volunteers (CONTROL) and analyzed the microcirculation in the following manner: Thenar muscle StO2 was measured non invasively by NIRS (InSpectra, Hutchinson Technology, USA) before and during upper limb ischemia. The basal StO2 and the rate of the StO2 decrease (down slope) were analyzed.
Results:
Conclusion: As the rate of StO2 down slope has been related to the rate of O2 consumption, we can hypothesize an altered O2 uptake which can result in a tissular hypoxia both in SEPTIC and PLT patients. Moreover basal StO2 may suggest that the intrinsic mechanism of the altered O2 consumption may be: microvascular shunting for sepsis (high basal StO2) and intense vasoconstriction for PLT patients (low basal StO2). However further research is required to confirm these assumptions. StO2 monitoring may be useful as an indicator of a diminished consumption as a marker of hypoxia during septic or hemorrhagic shock.
Reference(s):
Mc Kinley B A et al. J Trauma. 2000 Apr;48(4):637-42.
De Blasi R A et al. Intensive Care Med. 2005;31:1661-1668.