Please see Bibliography of References for a list of abstracts, manuscripts and posters.
Borrat X, Sanchez-Etayo G, Adalia R, Arguis MJ, Tercero FJ, Barroso M, Benito S, Zavala E. Eur J Anaesthesiol. 2006;23(Supp 37):197. Abstract A-764.
Background and Goal of Study: In shock septic patients is well known that tissue microcirculation is altered despite of an increased tissue oxygen tension (1,2). Probably because of a reduced cellular oxygen consumption. We've done a prospective observational study to determine changes in the rate of thenar muscles tissue deoxygenation during stagnant ischemia in patients with severe sepsis and septic shock.
Patients and Methods: Five shock septic patients were included in a preliminary study during the firsts days of sepsis evolution. Thenar muscle St02 was measured noninvasively by NIRS (InSpectra®, Hutchinson Technology, USA) before and during upper limb ischemia. The rate of St02 decrease (downslope) and increase (upslope) after limb ischemia were analyzed during the three days measurements. SOFA score, Cardiac output, lactate and the use of vasoactive drugs were also recorded.
Results and Discussions:
Conclusion(s): In septic shock patients, thenar muscle oxygen saturation during stagnant ischemia the rate of St02 decrease is slow as well as the increase in St02 during reperfusion after cuff release. Both determinations increases during the good evolution and stabilization of Severe sepsis. St02 monitoring may be useful as an indicator of septic shock patients.
References:
1 Sair M, Etherington PJ, Peter Winlove C, et al. Crit.Care Med. 2001;29:1343-1348.
2 De Blasi RA, Palmisani S, Alampi D, et al. Intensive Care Med.2005;31:1661-1668.