Please see Bibliography of References for a list of abstracts, manuscripts and posters.
Afaq A, Montgomery PS, Scott KJ, Blevins SM, Whitsett TL, Gardner AW. Angiology. 2008;59(5):534-541.
The purpose was to compare calf muscle hemoglobin oxygen saturation and exercise performance in hypercholesterolemic and normocholesterolemic patients with peripheral arterial disease. Hypercholesterolemic and normocholesterolemic patients had similar ankle/ brachial index (0.72 ± 0.24 vs 0.79 ± 0.28, [mean ± SD]; P = .334). Hypercholesterolemic patients had shorter initial claudication distance (214 ± 168 m vs 331 ± 185 m, P = .026), absolute claudication distance (391 ± 219 m vs 549 ± 211 m, P = .035), and lower calf muscle hemoglobin oxygen saturation at the occurrence of initial claudication distance (27 ± 21% vs 39 ± 20%; P = .013), and absolute claudication distance (26 ± 21% vs 36 ± 21%; P = .021). Hypercholesterolemia is associated with shorter walking distances and calf muscle hemoglobin oxygen saturation during exercise in patients limited by intermittent claudication.