Review Articles Hemorrhage Sepsis Microvascular Dysfunction Proof of Concept Other References
Please see Bibliography of References for a list of abstracts, manuscripts and posters.
Sepsis

Effects of increasing mean arterial pressure with norepinephrine on microvascular reactivity in septic shock patients
Thooft A, Favory R, Salgado DR, De Backer D, Vincent JL, Creteur J. Int Care Med. 2009;35(Suppl 1):S80. [Abstract]

Comparison of different vascular occlusion tests to assess microcirculatory disturbances with NIRS
Mayeur C, Campard S, Richard C, Teboul JL. Int Care Med. 2009;35(Suppl 1):S81. [Abstract]

Comparison of two transducers (15 or 25 mm) for thenar eminence micro-oxygenation assessment in septic shock
Luengo C, Damoisel C, Kerever S, Resche-Rigon M, Poussant T, Vall¨¦e D, Payen D. Int Care Med. 2009;35(Suppl 1):S27. [Abstract]

Is there a correlation between near infrared spectroscopy and side dark field imaging?
Favory, Ospina-Tascon G, Donadello K, Simion D, Neves AP, Occhipinti G, Oliveira T, Fonseca A, Creteur J, Vincent JL, De Backer D. Int Care Med. 2009;35(Suppl 1):S205. [Abstract]

Muscle oxygen consumption is related to the degree of microvascular dysfunction in patients with severe sepsis
Creteur J, Neves AP, Ospina G, De Backer D, Vincent JL. Int Care Med. 2009;35(Suppl 1):S104. [Abstract]

Effects of intravenous IGM-enriched immunoglobulins on muscle tissue mircrocirculation in septic shock: a preliminary report
Cavazzuti I, Rinaldi L, Braccini MS, Bertolotti V, Andreotti A, Busani S, Girardis M. Int Care Med. 2009;35(Suppl 1):S239. [Abstract]

Near infrared spectroscopy (NIRS) and its comparison with traditional parameters of oxygen delivery in septic intensive care patients
Allan C, Philips H, Kemp J, Celinski M, Jonas M. Int Care Med. 2009;35(Suppl 1):S28. [Abstract]

Accuracy of near infrared spectroscopy in predicting central venous mixed oxygenation in the emergency department
Napoli A, Forcada A, Corl K, Gardiner F. Acad Emerg Med. 2009;16(S1):S8. [Abstract]

Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients
Lima A, van Bommel J, Jansen TC, Ince C, Bakker J. Crit Care. 2009;13(Suppl 5):S13. [Abstract]

Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy
Donati A, Romanelli M, Botticelli L, Valentini A, Gabbanelli V, Nataloni S, Principi T, Pelaia P, Bezemer R, Ince C. Crit Care. 2009;13(Suppl 5):S12. [Abstract]

Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation
Creteur J, Neves AP, Vincent JL. Crit Care. 2009;13(Suppl 5):S11. [Abstract]

Is thenar tissue hemoglobin oxygen saturation in septic shock related to macrohemodynamic variables and outcome?
Payen D, Luengo C, Heyer L, Resche-Rigon M, Kerever S, Damoisel C, Losser MR. Crit Care. 2009;13(Suppl 5):S6. [Abstract]

Non-invasive assessment of the microcirculation in critically ill patients
Nanas S, Gerovasili V, Renieris P, Angelopoulos E, Poriazi M, Kritikos K, Siafaka A, Baraboutis I, Zervakis D, Markaki V, Routsi C, Roussos C. Anaesth Int Care. 2009;37(5):733-739. [Abstract]

Normalisation of tissue oxygen saturation in ED patients with severe sepsis or septic shock is related to mortality
Vorwerk C. Emerg Med J. 2009;26(Suppl 1):6. [Abstract]

Oxygen tissue saturation is lower in nonsurvivors than in survivors after early resuscitation of septic shock
Leone M, Blidi S, Antonini F, Meyssignac B, Bordon S, Garcin F, Charvet A, Blasco V, Albanese J, Martin C. Anesthesiology. 2009;111:366-371. [Abstract]

Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients
Mesquida J, Masip J, Gili G, Artigas A, Baigorri F. Int Care Med. 2009;35(6):1106-1109. [Abstract]

Effects of plasma expansion on recretement microvascular studied by infrared spectroscopy in patients with septic shock [in French]
Georger JF, Teboul JL, Chaari A, Monnet X, Richard C. 37th Congress of the Societe de Reanimation de Langue Francaise (SRLF); January 14-16, 2009; Paris, France. [Abstract]

Septic shock resuscitated and test ischemia monitored by NIRS: prognostic value and evolution over time and under vasoconstrictors [in French]
Levy B, Perez P, Thivilier C, Jacques T, Gerard A, Boussat S, Conrad M. 37th Congress of the Societe de Reanimation de Langue Francaise (SRLF); January 14-16, 2009; Paris, France. [Abstract]

Near infrared spectroscopy as a potential surrogate for mixed venous oxygen saturation for evaluation of patients with hemodynamic derangements
Crawford J, Otero R, Rivers E, Goldsmith D. ISICEM; March 18-21, 2008; Brussels, Belgium. [Abstract]

Near infrared spectroscopy to assess systemic perfusion in the critically ill
Crawford J, Otero R, Rivers E, Goldsmith D, Ristova S. SCCM Critical Care Congress; February 2-6, 2008; Honolulu, HI. [Abstract]

The prognostic value of NIRS-derived variables in patients with severe sepsis
Creteur J, Neves AP, Ospina G, Oliveira T, De Backer D, Vincent JL. Crit Care Med. 2008;36(12, Abstract Supplement):A158. Abstract 621. [Abstract]

NIRS determination of tissue oxygenation in sepsis
Creteur J, Vincent JL. Intl J Int Care. 2008;Summer:19-22. [Abstract]

Microcirculatory changes after activated protein-C infusion in severe sepsis
Donati A, Romanelli M, Romagnoli L, Botticelli L, Anastasi C, Pelaia P. Int Care Med. 2008;34(Supp 1):S104. Abstract 0395. [Abstract]

Tissue perfusion evaluation with near-infrared spectroscopy during treatment with activated protein C
Donati A, Botticelli L, Anastasi C, Romanelli M, Romagnoli L, Beato V, Pelaia P. Crit Care. 2008;12(Supp 2):S26-S27. Abstract P67. [Abstract]

The course of StO2 (NIRS) and dynamic tests with patients septische shock treated with activated drotrecogin alfa
Ferrandiere M, Lamy F, Tellier AC, Fantin G, Lagarrigue F, Laffon M, Fusciardi J. 36th Congress of the Societe de Reanimation de Langue Francaise; January 18, 2008; Paris, France. [Abstract]

Effects of activated protein C on microcirculation assessed by near infrared spectroscopy
Georger JF, Chaari A, Richard C, Teboul JL. Int Care Med. 2008;34(Supp 1):S256. Abstract 1004. [Abstract]

Effects of fluid resuscitation on microcirculation assessed by near infrared spectroscopy in septic patients
Georger JF, Chaari A, Richard C, Teboul JL. Int Care Med. 2008;34(Supp 1):S66. Abstract 0247. [Abstract]

Near-infrared spectroscopy to monitor tissue oxygenation in critically ill patients
Hinkelbein J, Rokuss K, Kalenka A, Bender H. Eur J Anaesthesiol. 2008;25(Suppl S44):3AP5-9. [Abstract]

Noninvasive monitoring of peripheral perfusion with physical examination and the peripheral flow index correlates with dynamic near-infrared spectroscopy measurements in patients with septic shock
Lima A, Jansen T, Ince C, Bakker J. Crit Care. 2008;12(Supp 2):S23-S24. Abstract P60. [Abstract]

Thenar oxygen saturation measured by near-infrared spectroscopy: a mortality predictor in septic patients
Mesquida J, Martinez M, Artigas A, Baigorri F. Int Care Med. 2008;34(Supp 1):S256. Abstract 1003. [Abstract]

Tissular oxygen saturation measured by near-infrared spectroscopy as a non-invasive predictor of low central venous oxygen saturation: a useful parameter in our resuscitation algorithm?
Mesquida J, Masip J, Gili G, Sabatier C, Baigorri F, Artigas A. Am J Respir Crit Care Med. 2008;177(Abstracts Issue):A366. [Abstract]

The relationship between near infrared spectroscopy and end tidal carbon dioxide in patients presenting with shock
Miner JR, Petersen G, Byrd C, Clinton J, Smith S. Ann Emerg Med. 2008;52(4, Supplement):S57-S58. Abstract 51. [Abstract]

Near infrared spectroscopy during stagnant ischemia a marker of ScvO2 – SvO2 mismatch in septic patients with low cardiac output
Mozina H, Podbregar M. Crit Care. 2008;12(Suppl 2):S28-S29. Abstract P72. [Abstract]

Near-infrared spectroscopy in patients with severe sepsis: correlation with invasive hemodynamic measurements
Mulier KE, Skarda DE, Taylor JH, Myers DE, McGraw MK, Gallea BL, Beilman GJ. Surg Infect. 2008;9(5):515-519. [Abstract]

Does red blood cell transfusion improve tissue oxygenation in critically ill patients?
Neves A, Ventura A, Boreli V, Zattar F, Creteur J, Vincent J. Int Care Med. 2008;34(Supp 1):S257. Abstract 1010. [Abstract]

A comparison of near infra-red spectroscopy with endpoints of resuscitation for evaluation of critically ill patients
Otero R, Crawford J, Goldsmith D, Ristova S. ISICEM; March 18-21, 2008; Brussels, Belgium. [Abstract]

Can transcutaneous oxygen saturation be used to detect tissue hypoperfusion?
Steinbuechel T, Peiniger S, Bouillon B, Wappler F, Sakka S. Int Care Med. 2008;34(8):1546-1547. [Abstract]

Non-invasive tissue oxygen monitoring in septic shock patients: an observational study
Borrat Frigola X, Mercadal J, Tercero F, Adalia R, Arguis M, Heering C, Zavala E. Int Care Med. 2007;33(Supp 2):S47. Abstract 0170. [Abstract]

The importance of oxygen saturation of tissue measured by near infrared light for the surveillance of patient where the peripheral circulation is supported after reanimation [in French]
Camus T, Brun P, Malissin I, Deye N, Modestin L, Megarbane B, Baud F. SFAR 49th National Congress of Anesthesia and Resuscitation; September 26-29, 2007; Paris, France. [Abstract]

Near infrared spectroscopy to assess systemic perfusion in the critically ill
Crawford J, Otero R, Goyal N, Sankey S, Rivers E. Crit Care Med. 2007;35(12, Abstract Supplement):A254. Abstract 913. [Abstract]

The prognostic value of muscle StO2 in septic patients
Creteur J, Carollo T, Soldati G, Buchele G, De Backer D, Vincent J-L. Int Care Med. 2007;33(9):1549-1556. [Abstract]

Muscle oxygen saturation cannot predict central venous oxygen saturation in patients with severe sepsis
Creteur J, Ospina G, Oliveira Silva T, De Backer D, Vincent J. Int Care Med. 2007;33(Supp 2):S6. Abstract 0006. [Abstract]

Impairments in microvascular reactivity are related to organ failure in human sepsis
Doerschug KC, Delsing AS, Schmidt GA, Haynes WG. Am J Physiol Heart Circ Physiol. 2007;293(2):H1065-H1071. [Abstract]

Can near infrared spectroscopy detect functional microcirculation abnormalities in septic patients?
Georger JF, Chaari A, Richard C, Teboul JL. Int Care Med. 2007;33(Supp 2):S254. Abstract 0987. [Abstract]

Effects of norepinephrine on regional perfusion assessed by near infrared spectroscopy in patients with septic shock
Georger JF, Chaari A, Richard C, Teboul JL. Int Care Med. 2007;33(Supp 2):S166. Abstract 0641. [Abstract]

Advantage and feasibility of using the InSpectra 325™ Tissue Spectometer in an emergency department
Kierzek G, Didden S, Bonnetain F, Deville C, Pourriat JL. Anesthesiology. 2007;107:A1270. [Abstract]

Vasopressin substitution causes microcirculatory changes in patients with septic shock
Klinzing S, Reinhard C, Simon T, Schurholz T, Sakr Y, Reinhart K, Marx G. Crit Care. 2007;11(Suppl 2):S13-S14. Abstract P34. [Abstract]

Prognostic value of StO2 in septic shock [in French]
Leone M, Messignac B, Figueiredo S, Zieleskiewicz L, Blasco V, Albanese J, Martin C. SFAR 49th National Congress of Anesthesia and Resuscitation; September 26-29, 2007; Paris, France. [Abstract]

Evaluation of thenar hemoglobin oxygen saturation (StO2) items as outcome markers at day 0 of human septic shock
Payen D, Damoisel C, Heyer L, Luengo C, Kerever S, Losser MR. Crit Care Med. 2007;35(12, Abstract Supplement):A271. Abstract 975. [Abstract]

Assessment by StO2 of peripheral tissue perfusion improvement with activated protein C (APC) in human septic shock
Payen D, Heyer L, Damoisel C, Kerever S, Luengo C, Losser MR. Crit Care Med. 2007;35(12, Abstract Supplement):A279. Abstract 1005. [Abstract]

Skeletal muscle oxygen saturation does not estimate mixed venous oxygen saturation in patients with severe left heart failure and additional severe sepsis or septic shock
Podbregar M, Mozina H. Crit Care. 2007;11(1):R6. [Abstract]

Skeletal muscle dynamic near-infraread spectroscopy measurements in patients with septic shock
Pujol W, Vargas F, Bui HN, Clouzeau B, Herpe B, Medrano J, Garnier S, Boyer A, Pillet O, Gruson D, Hilbert G, Gbikpi-Benissan G, Castaing Y. Crit Care Med. 2007;35(12, Abstract Supplement):A77. Abstract 293. [Abstract]

Searching for non-invasive markers of tissue hypoxia
Puyana JC, Pinsky MR. Crit Care. 2007;11(1):116. [Abstract]

Near-infrared spectroscopy to monitor tissue oxygenation in critically ill patients
Rokuss K, Hinkelbein J, Kalenka A, Bender HJ. 9th Capital City Conference of the DGAI Congress of Anesthesiology and Intensive Care Medicine – HAI 2007; September 13-15, 2007; Berlin, Germany. [Abstract]

Tissue oxygen saturation: an indicator for systemic oxygenation in experimental sepsis
Simon T, Schuerholz T, Petzel P Haugvik S, Klinzing S, Marx G. Int Care Med. 2007;33(Supp 2):S31. Abstract 0105. [Abstract]

Dynamic near-infrared spectroscopy measurements in patients with severe sepsis
Skarda DE, Mulier KE, Myers DE, Taylor JH, Beilman GJ. Shock. 2007;27(4):348-353. [Abstract]

NIRS assessment of microcirculation in septic and polytraumatized patients
Borrat X, Sanchez-Etayo G, Mercadal J, Tercero F, De la Riba N, Israel T, Adalia R, Zabala E. Int Care Med. 2006;32(Supp 1):S172. Abstract 0657. [Abstract]

Non-invasive tissue oxygen monitoring in septic shock patients: an observational study
Borrat X, Sanchez-Etayo G, Adalia R, Arguis MJ, Tercero FJ, Barroso M, Benito S, Zavala E. Eur J Anaesthesiol. 2006;23(Supp 37):197. Abstract A-764. [Abstract]

Muscle oxygen consumption is decreased in septic patients
Creteur J, Buchele G, Sales Jr J, Ospina G, Vincent J. Int Care Med. 2006;32(Supp 1):S290. Abstract 1126. [Abstract]

Differential micro-oxygenation dysfunction in haemorrhagic and septic shock patients
Heyer L, Madadaki C, Rezlan E, Welschbillig S, Mateo J, Payen D. Int Care Med. 2006;32(Supp 1):S254. Abstract 0982. [Abstract]

Microcirculatory changes in patients with sepsis or septic shock under vasopressin substitution
Klinzing S, Reinhard C, Simon T, Reinhart K, Marx G. Int Care Med. 2006;32(Supp 1):S201. Abstract 0773. [Abstract]

Oxygen tissular saturation (StO2) measured by NIRS in patients admitted to the intensive care unit
Mesquida J, Maluenda M, Masip J, Baigorri F, Artigas A. Int Care Med. 2006;32(Supplement 1):S167. Abstract 0640. [Abstract]

Muscle oxygenation in low flow state and sepsis: correlation to hemodynamics and outcome
Mozina H, Strahovnik I, Podbregar M. Int Care Med. 2006;32(Supp 1):S290. Abstract 1128. [Abstract]

Comparison of the effects of noradrenaline and adrenaline on tissue oxygen saturation in cases of septic shock. A feasibility study [in French]
Nguyen A, Nardi O, Lemaout C, Aboab J, Gonzalez H, Orlikowski O, Annane D. Reanimation. 2006;15(Supp 1):S248. Abstract SP369. [Abstract]

Near infrared spectroscopy as an indicator of systemic perfusion in acutely ill patients in the emergency department
Otero R, Crawford J, Rivers EP, Nwoke P, Sankey SS. American College of Emergency Physicians (ACEP) Research Forum; October 15-16, 2006; New Orleans, LA. [Abstract]

Changes in muscle tissue oxygenation during stagnant ischemia in septic patients
Pareznik R, Knezevic R, Voga G, Podbregar M. Int Care Med. 2006;32(1):87-92. [Abstract]

Changes in the microcirculation during human endotoxemia measured with near-infrared spectroscopy
Pickkers P, Gotink K, Draisma A, van der Hoeven H. Crit Care. 2006;10(Supp 1):S133. Abstract P320. [Abstract]

Tissue-oxygenation assessment using near-infrared spectroscopy during severe sepsis: confounding effects of tissue edema on StO2 values
Poeze M. Int Care Med. 2006;32(5):788-789. [Abstract]

Microcirculatory dysfunction in ICU patients with sepsis
Renieris P, Gerovasili V, Poriazi M, Loukas T, Markaki V, Routsi C, Roussos C, Nanas S. Int Care Med. 2006;32(Supp 1):S98. Abstract 0371. [Abstract]

Muscle tissue oxygenation in septic patients treated with activated protein C
Rinaldi L, Busani S, Girardis M. Int Care Med. 2006;32(Supp 1):S178. Abstract 0681. [Abstract]

Effects of activated protein C on the microvascular response to reactive hyperemia in patients with septic shock
Sales Jr J, Buchele GL, Ospina GA, Creteur J, Vincent JL. Int Care Med. 2006;32(Supp 1):S290. Abstract 1125. [Abstract]

Effects of activated protein C on endothelial function during sepsis [in French]
Tonnelier JM, Goetghebeur D, Gut-Gobert C, Renault A, Boles JM, L’Her E. Reanimation. 2006;15(Supp 1):S183. Abstract SP 246. [Abstract]

Sublingual NIRS and reflectance spectrophotometry: new methods to monitor sublingual oxygen availability
Atasever B, van der Veen A, Goedhart P, de Mol B, Ince C. 25th International Symposium on Intensive Care and Emergency Medicine; March 21-25, 2005; Brussels, Belgium. [Abstract]

Impact of time on systemic and local evaluation of perfusion/oxygenation during septic shock
Heyer L, Madadaki K, Rezlan E, Mateo J, Losser MR, Payen D. Int Care Med. 2005;31(Supp 1):S16. Abstract 044. [Abstract]

Impact of time on systemic and local evaluation of perfusion/oxygenation during septic shock
Heyer L, Madadaki K, Rezlan E, Mateo J, Losser MR, Payen D. ESICM Meeting; September 25-28, 2005; Amsterdam, The Netherlands. [Abstract]

Non-invasive thenar muscle tissue oxygen saturation as a surrogate of central venous oxygen saturation in patients with severe sepsis
Kwon Y, Lee SH, Ryoo HC, Patrick H. Crit Care Med. 2005;33(12, Abstract Supplement):A167. Abstract 223-T. [Abstract]

Effects of recombinant human activated protein C on endothelial function during sepsis
L’Her E, Goetghebeur D, Tonnelier J, Gut-Gobert C, Boumediene A, Renault A, Boles J. Effects of recombinant human activated protein C on endothelial function during sepsis. Int Care Med. 2005;31(Supp 1):S43. Abstract 153. [Abstract]

Correlation between noninvasive oxygen tissue saturation (StO2) measurements by near-infrared spectroscopy and invasive central venous oxygen saturation (SvO2)
L’her E, Goetghebeur D, Tonnelier JM, Prat G. American Thoracic Society International Conference; May 20-25, 2005; San Diego, CA. [Abstract]

Dynamic near-infrared spectroscopy measurements in patients with severe sepsis correlate with invasive hemodynamic measurements
Skarda D, Taylor J, Mulier K, Myers D, Beilman G. Crit Care. 2005;9(Supp 1):S30. Abstract P74. [Abstract]

Dynamic near-infrared spectroscopy measurements in patients with severe sepsis correlate with invasive hemodynamic measurements
Skarda D, Taylor J, Mulier K, Myers D, Beilman G. 25th International Symposium on Intensive Care and Emergency Medicine; March 21-25, 2005; Brussels, Belgium. [Abstract]

Microvascular response to reactive hyperemia is altered in septic patients
Carollo T, Creteur J, De Backer D, Vincent JL. Int Care Med. 2004;30(Supp 1):S24. Abstract 074. [Abstract]

Persistent altered microvascular reactivity is predictive of mortality in septic patients
Carollo T, Creteur J, De Backer D, Vincent JL. Int Care Med. 2004;30(Supp 1):S163. Abstract 626. [Abstract]

Improvement of muscle tissue deoxygenation during stagnant ischemia in survivors of severe sepsis
Pareznick R, Voga G, Knezevic R, Podbregar M. Int Care Med. 2004;30(Supp 1):S144. Abstract 554. [Abstract]





The InSpectra™ StO2 Tissue Oxygenation Monitor provides a noninvasive, continuous, real-time, and direct measurement of hemoglobin oxygen saturation in tissue (StO2), providing trauma teams the ability to measure tissue oxygen saturation and monitor it during resuscitation. It is the only perfusion status monitor designed for trauma environments. The InSpectra StO2 Tissue Oxygenation Monitor uses near infrared light to illuminate tissue, and then analyzes the returned light to produce a quantitative measurement of oxygen saturation in the tissue's microcirculation.

The StO2 Trauma Study researched the role that tissue oxygen saturation monitoring could play in hemorrhagic shock and resuscitation. Study results demonstrate that StO2 measurements less than 75% may indicate serious hypoperfusion in trauma patients and that StO2 functions as well as base deficit in indicating hypoperfusion in trauma patients.