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Septic Shock

The InSpectra™ StO2 Tissue Oxygenation Monitor has not been cleared by the FDA for use in diagnosing sepsis or septic shock. Additional clinical studies are required to establish the value of these measurements in assessing patient status relating to sepsis or septic shock. Click here to see the complete Indications for Use.



Microvascular Response to Reactive Hyperemia is Altered in Septic Patients
Carollo T1, Creteur J1, De Backer D1, Vincent JL1.
1 Intensive Care, Erasme Hospital, Bruxelles, Belgium
Presented at the 17th ESICM Annual Congress, Berlin, Germany, 10-13 October 2004.

Alterations in vascular reactivity can be demonstrated by the InSpectra™ System technique in septic patients.



Persistent Altered Microvascular Reactivity is Predictive of Mortality in Septic Patients
Carollo T1, Creteur J1, De Backer D1, Vincent JL1.
1Intensive Care, Erasme Hospital, Bruxelles, Belgium
Presented at the 17th ESICM Annual Congress, Berlin, Germany, 10-13 October 2004.

The InSpectra™ System was used to monitor vascular reactivity in septic patients. The persistence of an altered microvascular response to reactive hyperaemia following an arterial occlusion is associated with a worse outcome in septic patients.



Improvement of Muscle Tissue Deoxygenation During Stagnant Ischemia in Survivors of Severe Sepsis
Pareznik R1, Voga G1, Knezevic R1, Podbregar M1
1Department for Internal Intensive Medicine, General Hospital Celje, Celje, Slovenia
Presented at the 17th ESICM Annual Congress, Berlin, Germany, 10-13 October 2004

Following a brief arterial occlusion, the InSpectra™ System was used to monitor the slope of muscle tissue deoxygenation. The rate of muscle tissue deoxygenation during stagnant ischemia could potentially be used as a marker of oxygen uptake capability in septic patients.



Muscle Perfusion and Oxygen Consumption by Near-Infrared Spectroscopy in Septic-Shock and Non-Septic-Shock Patients
Girardis M, Rinaldi L, Busani S, Flore I, Mauro S, Pasetto A
Intens Care Med. 2003;29:1173-1176

Near infrared spectroscopy of skeletal muscle tissue combined with venous occlusion allows a rapid, noninvasive, and simultaneous assessment of regional perfusion and oxygen consumption.





The InSpectra™ StO2 Tissue Oxygenation Monitor provides a direct, absolute measurement of hemoglobin oxygen saturation in tissue (StO2), providing trauma teams the ability to measure tissue oxygenation and monitor it during resuscitation. It is the only tissue oxygenation monitor designed for trauma environments. The InSpectra StO2 Tissue Oxygenation Monitor uses near infrared light to illuminate tissue, and then analyzes the returned light to produce a quantitative measurement of oxygen saturation in the tissue's microcirculation.

The StO2 Trauma Study researched the role that tissue oxygen saturation monitoring could play in hemorrhagic shock and resuscitation. Study results demonstrate that StO2 measurements less than 75% may indicate serious hypoperfusion in trauma patients and that StO2 functions as well as base deficit in indicating hypoperfusion in trauma patients.